A comprehensive review and meta-analysis undertaken by Manicone PF, De Angelis P, Rella E, Papetti L, and D'Addona A explored the prevalence of proximal contact loss in restorations supported by dental implants. This journal stands as a significant resource for prosthodontic scholarship. Article 201-209, positioned within volume 31, issue 3, of the journal, was published in March 2022. From the article with the doi101111/jopr.13407, a fresh perspective emerges. Regarding the funding of the Epub 2021 Aug 5 paper, PMID 34263959, no details were included.
A meta-analysis of a systematic review.
Meta-analysis employed within a comprehensive systematic review.
The publication process often favors studies that yield statistically substantial results over those lacking statistical significance. This phenomenon is frequently associated with publication bias or small-study effects, which subsequently significantly impact the reliability of conclusions in systematic reviews and meta-analyses. Small-scale studies frequently manifest effects that exhibit a consistent directionality, contingent on whether the intended impact is helpful or harmful, but conventional methodologies often fail to incorporate this crucial factor.
We recommend implementing directional testing strategies to identify potential outcomes from small-scale studies. Egger's regression test forms the foundation of the one-sided testing framework employed in these tests. To compare the performance of the proposed one-sided regression tests, simulation studies were carried out, alongside conventional two-sided regression tests, alongside alternative methods like Begg's rank test and the trim-and-fill method. By using type I error rates and statistical power, their performance was evaluated objectively. In addition to other evaluation methods, three real-world meta-analyses focused on infrabony periodontal defect measurements were used to scrutinize the performance of various methodologies.
Simulation studies have shown that one-sided tests often demonstrate a considerably more potent statistical power than their competing two-sided alternatives. Their rate of Type I errors was, by and large, kept in check. Analyzing three actual meta-analyses, one-sided tests, by acknowledging the preferred direction of outcomes, can help eliminate the chance of erroneous conclusions regarding the impact of smaller studies. The presence of true small-study impacts makes these approaches more effective at evaluation than the customary two-sided tests.
To assess small-study effects, researchers are advised to include the anticipated direction of the effects in their evaluation.
Researchers are encouraged to include the potential directional bias in assessments of outcomes from smaller studies.
To compare the relative efficacy and safety of antiviral agents in the prevention and treatment of herpes labialis, a network meta-analysis of clinical trials is employed.
A systematic review of the literature was performed, encompassing Ovid Medline, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Clinicaltrials.gov. Randomized controlled trials (RCTs) of antiviral agents in healthy, immunocompetent adults for the treatment and prevention of herpes labialis need to compare outcomes. Data extraction from the selected RCTs was followed by an assessment and the subsequent execution of a network meta-analysis (NMA). Utilizing the surface under the cumulative ranking (SUCRA) principle, the interventions were sorted in order of their ranking.
A qualitative synthesis utilized 52 articles. For the quantitative part, 26 articles were analyzed relating to the primary treatment outcome, and a further 7 articles assessed the primary prevention outcome. The combination treatment of oral valacyclovir and topical clobetasol achieved the top ranking, resulting in a mean reduction in healing time of -350 (95% confidence interval: -522 to -178). Vidarabine monophosphate therapy was the second-best performer, with a mean reduction of -322 (95% confidence interval: -459 to -185). MSAB No significant publication bias, heterogeneity, or inconsistencies were reported in the findings of the TTH outcome analysis. Seven randomized controlled trials, focusing on primary prevention outcomes, met the inclusion criteria; yet, no intervention demonstrated superiority over its counterparts. The absence of adverse events was reported across 16 studies; meanwhile, other research indicated the presence of only mild side effects.
NMA's analysis showed that various agents were effective in managing herpes labialis, and the combined application of oral valacyclovir and topical clobetasol proved to be the most effective in minimizing the recovery period. Determining the most effective intervention to prevent herpes labialis recurrences necessitates additional research efforts.
NMA reported that various agents effectively treated herpes labialis, the most successful approach being the concurrent use of oral valacyclovir and topical clobetasol, significantly shortening the healing duration. In order to determine the superior intervention for the prevention of herpes labialis recurrences, more studies are necessary.
The recent trend in oral health care settings has been a redirection in the evaluation of treatment outcomes, replacing the clinician's perspective with one based on the patient's perception. Endodontic procedures are a specialized area of dentistry, aiming to address and prevent diseases affecting the dental pulp and periapical regions. Endodontic research and its related treatment efficacy assessments have predominantly concentrated on clinician-reported outcomes (CROs), neglecting dental patient-reported outcomes (dPROs). Hence, researchers and clinicians should give considerable focus to the significance of dPROs. This review will survey dPROs and dPROMs in endodontic practice, aiming to clarify the patient experience, stress the importance of a patient-centered approach to treatment, and advocate for improvements in patient care, while also prompting more research concerning dPROs. Following endodontic procedures, common adverse outcomes include pain, tenderness, impaired tooth function, the necessity of additional interventions, undesirable side effects such as worsened symptoms and discoloration, and a negative impact on Oral Health-Related Quality of Life. MSAB dPROs are indispensable for endodontic treatment outcomes, helping clinicians and patients determine the most suitable management approaches, leading to improved preoperative evaluations, better preventive and therapeutic strategies, and more sophisticated clinical study methodology and design. MSAB In endodontic practice and research, prioritizing patient care is essential, and routine analysis of dPROs should be performed using sound and appropriate techniques. The absence of universally accepted standards for reporting and defining endodontic treatment outcomes fuels the development of a comprehensive Core Outcome Set for Endodontic Treatment Methods (COSET). A new assessment tool, exclusive to the future of endodontic treatment, should accurately depict the perspectives of patients.
This review investigates the diagnostic potential of cone-beam computed tomography (CBCT) in detecting external root resorption (ERR) in both in vivo and in vitro studies. A critical analysis of past and current methods for measuring and classifying ERR in vivo/in vitro, in terms of radiation exposures and long-term risks, is also conducted.
Adhering to PRISMA guidelines, a systematic review of diagnostic methods employed a protocol focused on diagnostic test accuracy (DTA). In accordance with protocol, PROSPERO registered the study under ID CRD42019120513. The ISSG Search Filter Resource guided the thorough and exhaustive electronic search encompassing six core electronic databases. PICO statements (Population, Index test, Comparator, Outcome) were used to formulate the eligibility criteria, and the methodological quality was then evaluated using QUADAS-2.
Of the 7841 articles submitted, seventeen were ultimately selected. Six in vivo studies were judged to have a low risk of bias, according to the assessment. The sensitivity and specificity of CBCT in the diagnosis of ERR were 78.12% and 79.25%, respectively. The sensitivity and specificity of CBCT in diagnosing external root resorption are characterized by a broad spectrum, with sensitivity ranging from 42% to 98% and specificity from 493% to 963%.
The selected studies, possessing multislice radiographs, frequently used single linear measurements for their quantitative ERR diagnoses. An increase in the cumulative radiation dose (S) was observed in radiation-sensitive structures, such as bone marrow, brain, and thyroid, employing the 3-dimensional (3D) radiography procedures reported.
CBCT's diagnostic range for external root resorption encompasses sensitivity from 42% to 98%, and specificity from 493% to 963%. The minimum and maximum effective radiation doses necessary for diagnosing external root resorption via dental cone beam computed tomography (CBCT) are 34 Sv and 1073 Sv, respectively.
In diagnosing external root resorption, the highest sensitivity and lowest specificity achievable with CBCT are 98% and 493%, respectively, while the lowest sensitivity and highest specificity are 42% and 963%, respectively. The effective doses for dental CBCT, ranging from a minimum of 34 Sieverts to a maximum of 1073 Sieverts, are crucial for diagnosing external root resorption.
In the research team, Thoma DS, Strauss FJ, Mancini L, Gasser TJW, and Jung RE are listed. Patient-reported outcome measures: a systematic review and meta-analysis of minimal invasiveness in soft tissue augmentation at dental implants. Periodontol 2000, a periodical specializing in periodontics. On August 11, 2022, a publication appeared with a Digital Object Identifier (DOI) of 10.1111/prd.12465. This content is made accessible online ahead of its inclusion in print form. The PMID identifier is 35950734.
This occurrence was not documented.
A systematic review coupled with meta-analytic procedures.
A meta-analysis of a systematic review.
To scrutinize the reporting quality of systematic review (SR) abstracts featured in prominent general dental journals, employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Abstracts (PRISMA-A) framework, and to discover factors associated with the overall reporting quality.